Chromosome 15q duplication Cell Lines at the Human Genetic Cell Repository,
Coriell Institute for Medical Research
In the study of human genetic disorders, samples from patients and their families are a critical resource for researchers, however it is often a major hurdle to identify families with specific chromosome abnormalities, like idic(15) and int dup(15). Thus many researchers rely on tissue and cell “banks” for access to samples from patients with a specific diagnosis. These samples are often in the form of a “cell line”, which are derived from a blood sample that has been specifically treated to allow the cells to be grown in culture for extended periods of time. Our lab has established cell lines for most of the samples that we have obtained for our study of chromosome 15q duplications. We would like to submit them to the Human Genetic Cell Repository at the Coriell Institute for Medical Research to make them widely available to other researchers who are interested in working on chromosome 15.
The Human Genetic Cell Repository at the Coriell Institute for Medical Research in Camden, New Jersey, holds the world’s largest collection of human cell lines for use in research, which includes about 2000 genetic disorders. They maintain and distribute thousands of cell lines and DNA samples from individuals with diverse genetic disorders and make them available to researchers around the world for a nominal cost. Their collection is supported by grants from the National Institutes of Health and several private foundations with specific support by the National Institute of General Medical Sciences for the Human Genetic Cell Repository. To learn more about the Coriell cell repository, see their website: http://coriell.umdnj.edu/.
Coriell’s repository collects biological samples and relevant clinical information from donors. All personal identifying information is removed upon arrival to the Repository. In the catalog, basic information is provided to researchers ordering cell lines, including gender, race, the age of the individual when the sample was obtained, and if other family members are in the Repository. However, all of the information is anonymized, meaning that there is no way for the researcher to know who the sample came from.
Families who are participating in our study can contact the Human Genetic Cell Repository genetic counselor, Tina Sellers, to authorize us to share your cells. Be sure to let her know if you are part of our study, because if we have samples that can be shared, we will send the cells to Coriell so that you do not need to have another sample of blood drawn. If families are not enrolled in our study, but would like to provide a sample for the cell repository, you can also participate in this opportunity to expand access to idic(15) and int dup(15) cell lines by contacting Tina. All interested families will need to sign the Coriell consent forms in order to have their samples in the repository. These forms are being generated and will be available from Tina Sellers.
Tina Sellers, MS, CGC
Genetic Counselor, Coriell Cell Repositories
Coriell Institute for Medical Research
403 Haddon Avenue
Camden, NJ 08103
Phone: (856)966-5062
Fax: (856)757-9737
e-mail: tsellers@coriell.org
How do researchers know that the idic(15)/int dup(15) cell lines are available through Coriell?
The Coriell Cell Repositories are the best repository for human cell lines in the country and have a really nice searchable database that would help locate the samples (plus they can even match with control lines). They already have one cell line (GM04347) from a patient with an idic(15) although it is one from someone with a tiny dup chromosome. They have the best group of PWS and AS lines so people interested in 15q already know to go there, plus once we deposit the lines from our study there, we can refer to the Coriell number in our published papers- further advertising their existence.
As new IDEAS families ask us about how they can get involved in ongoing research, is there someone at Coriell who would coordinate the submission of new cell lines?
Tina Sellers, Genetic Counselor for the Coriell Cell Repositories can help coordinate direct submissions for folks who are interested in going that route. They did this for the Rett Syndrome Research Foundation and have about 80 Rett lines.
As researchers request idic(15)/int dup(15) cell lines, will IDEAS learn of their request?
The Coriell Cell Repository can provide IDEAS with a yearly report that details the number of idic(15)/int dup(15) cell lines that are shipped from the Repository. However, it is their policy that they do not release the names of researchers who order cell lines so IDEAS will not be able to learn where the cell lines are sent.
3rd Annual IDIC 15 5K Run/Walk Sunday September 14, 2008 at Killington Recrecation Field in Killington, VT
A physician's advisory has been issued by the IDEAS Professional Advisory Board.
June 25-27th, 2009 will be our next International IsoDicentric 15 Conference in Indianapolis, Indiana
29% |
 |
||
 |
 |
 |
|
 |
|||
$19,702 of $67,347 Donate Now |
|||
Donate
Volunteer
